NODES 2023 – Graphs Enabling Glycoscience

Increasing evidence indicates that tumor-associated glycans play an essential role during malignancy. Aberrant tumor-specific glycosylation is the result of alterations in glycan biosynthesis pathways. This intricate process involves multiple steps and can significantly impact a cell’s glycan repertoire. Glycans form tree-like structures, and the position and connectivity of individual monomers and their attachment to proteins are essential. Analysis of glycan patterns depends on how monomers are connected to each other and the number and order of monomers in tree-like
structures. In this session, Karina and Alex will describe how graphs represent clinically meaningful glycomic data and how Neo4j helps manage complex biological data collections to help fight cancer.